Last update
4/11/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Likely Ineffective
Based on 1 Research
4
USERS' SCORE
Moderately Good
Based on 67 Reviews
7.8
Supplement Facts
Serving Size: 4 capsules
Amount Per Serving
%DV
Chloride (from glucosamine hydrochloride potassium sulfate)
170 mg
7%
Sodium (from chondroitin sulfate sodium)
120 mg
5%
Potassium (from glucosamine hydrochloride potassium sulfate)
190 mg
4%
GlucosamineHydrochloride Potassium Sulfate
1500 mg
†
Chondroitin sulfate Sodium
1200 mg
†
MSM (Methylsulfonylmethane)(OptiMSM®)
1000 mg
†
Top Medical Research Studies
4
In our clinical trial, we investigated the effects of methylsulfonylmethane (MSM) combined with boswellic acids (BA) on individuals suffering from knee arthritis, a chronic condition often characterized by joint pain and inflammation. We enrolled 60 participants who were randomly divided into two groups: one group received the MSM and BA treatment for 60 days, and the other group was given a placebo.
Over the follow-up periods of 2 and 6 months, we measured pain levels using a visual analog scale (VAS) and assessed joint function with the Lequesne index (LI). While we found that participants taking MSM and BA reported higher pain levels than those on the placebo after 2 months, these differences did not persist at the 6-month mark. Furthermore, when evaluating joint function, we noted no significant differences between the two groups.
However, one notable finding was that those receiving the combination treatment needed fewer anti-inflammatory drugs compared to the placebo group at both follow-up points. Despite the reduced reliance on these medications, we concluded that combined treatment with MSM and BA did not significantly improve pain or joint function compared to placebo.
Over the follow-up periods of 2 and 6 months, we measured pain levels using a visual analog scale (VAS) and assessed joint function with the Lequesne index (LI). While we found that participants taking MSM and BA reported higher pain levels than those on the placebo after 2 months, these differences did not persist at the 6-month mark. Furthermore, when evaluating joint function, we noted no significant differences between the two groups.
However, one notable finding was that those receiving the combination treatment needed fewer anti-inflammatory drugs compared to the placebo group at both follow-up points. Despite the reduced reliance on these medications, we concluded that combined treatment with MSM and BA did not significantly improve pain or joint function compared to placebo.
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Most Useful Reviews
7.5
Significant improvement
250 people found this helpful
There is an effect - it works! I delayed writing a review as I wanted to observe the results. I ordered this drug for my mother-in-law, who has rheumatoid arthritis, and for my mother, suffering from intervertebral disc issues. Initially sceptical, they began taking the drug when pain forced them to agree. Within ten days, my mother-in-law noticed it was easier to rise from a chair, and the swelling in her knees diminished, though pain persisted. After two weeks, my mother could wake up on her side, something she hadn't managed due to back pain. They have now been taking the drug for over a month, and I'm reordering. They recommend it!
Read More
9
Best joint supplement
24 people found this helpful
This preparation is excellent compared to Teraflex and Arthra, which my mother, who has rheumatoid arthritis, used previously. This product contains more active ingredients at a significantly lower price. I confidently recommend this drug, as it truly benefits joint health.
Read More
9
Pain relief guaranteed
5 people found this helpful
This is the best product for my mother! She takes it as instructed for a week and then forgets about it, as the pain completely disappears. She has rheumatoid arthritis and is generally pleased. I recommend it!
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Ineffective
Based on 1 Research
4
- All Researches
4
In our clinical trial, we investigated the effects of methylsulfonylmethane (MSM) combined with boswellic acids (BA) on individuals suffering from knee arthritis, a chronic condition often characterized by joint pain and inflammation. We enrolled 60 participants who were randomly divided into two groups: one group received the MSM and BA treatment for 60 days, and the other group was given a placebo.
Over the follow-up periods of 2 and 6 months, we measured pain levels using a visual analog scale (VAS) and assessed joint function with the Lequesne index (LI). While we found that participants taking MSM and BA reported higher pain levels than those on the placebo after 2 months, these differences did not persist at the 6-month mark. Furthermore, when evaluating joint function, we noted no significant differences between the two groups.
However, one notable finding was that those receiving the combination treatment needed fewer anti-inflammatory drugs compared to the placebo group at both follow-up points. Despite the reduced reliance on these medications, we concluded that combined treatment with MSM and BA did not significantly improve pain or joint function compared to placebo.
Over the follow-up periods of 2 and 6 months, we measured pain levels using a visual analog scale (VAS) and assessed joint function with the Lequesne index (LI). While we found that participants taking MSM and BA reported higher pain levels than those on the placebo after 2 months, these differences did not persist at the 6-month mark. Furthermore, when evaluating joint function, we noted no significant differences between the two groups.
However, one notable finding was that those receiving the combination treatment needed fewer anti-inflammatory drugs compared to the placebo group at both follow-up points. Despite the reduced reliance on these medications, we concluded that combined treatment with MSM and BA did not significantly improve pain or joint function compared to placebo.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 67 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Significant improvement
250 people found this helpful
There is an effect - it works! I delayed writing a review as I wanted to observe the results. I ordered this drug for my mother-in-law, who has rheumatoid arthritis, and for my mother, suffering from intervertebral disc issues. Initially sceptical, they began taking the drug when pain forced them to agree. Within ten days, my mother-in-law noticed it was easier to rise from a chair, and the swelling in her knees diminished, though pain persisted. After two weeks, my mother could wake up on her side, something she hadn't managed due to back pain. They have now been taking the drug for over a month, and I'm reordering. They recommend it!
Read More
9
Best joint supplement
24 people found this helpful
This preparation is excellent compared to Teraflex and Arthra, which my mother, who has rheumatoid arthritis, used previously. This product contains more active ingredients at a significantly lower price. I confidently recommend this drug, as it truly benefits joint health.
Read More
9
Pain relief guaranteed
5 people found this helpful
This is the best product for my mother! She takes it as instructed for a week and then forgets about it, as the pain completely disappears. She has rheumatoid arthritis and is generally pleased. I recommend it!
Read More
8
Quality product
3 people found this helpful
I purchased this for my mother with rheumatoid arthritis. The drug is effective and made of high-quality ingredients. I highly recommend it!
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9
Helps stop cartilage destruction
1 people found this helpful
The product works! I bought it for my mother, who has rheumatoid arthritis. She claims it helps halt the destruction of cartilage. She undergoes a course every two months alongside cat's claw, and I am now getting her the second can.
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Frequently Asked Questions
9
Pain relief guaranteed
5 people found this helpful
This is the best product for my mother! She takes it as instructed for a week and then forgets about it, as the pain completely disappears. She has rheumatoid arthritis and is generally pleased. I recommend it!
9
Significant improvement
After about 2 weeks of taking it, my elderly relative’s rheumatoid arthritis showed significant improvement.
9
Highly recommended supplement
Excellent! This is the most efficient supplement for bones and joints! I provide it to my father and husband, who both suffer from rheumatoid arthritis and other joint issues. After three months of use, we have seen genuine improvements and substantial support. Highly recommended!
7.5
Helps with pain
My mum has rheumatoid arthritis, which often causes joint pain. This supplement helps her significantly. She takes it for a three-month course followed by a break.
7.5
Significant improvement
250 people found this helpful
There is an effect - it works! I delayed writing a review as I wanted to observe the results. I ordered this drug for my mother-in-law, who has rheumatoid arthritis, and for my mother, suffering from intervertebral disc issues. Initially sceptical, they began taking the drug when pain forced them to agree. Within ten days, my mother-in-law noticed it was easier to rise from a chair, and the swelling in her knees diminished, though pain persisted. After two weeks, my mother could wake up on her side, something she hadn't managed due to back pain. They have now been taking the drug for over a month, and I'm reordering. They recommend it!
9
Improved mobility
This product is essential for me as I have rheumatoid arthritis. After a year of use, my joint pain is no longer an issue. I believe it contains beneficial ingredients for my age and has improved my mobility.
9
Very effective treatment
Works! I give this to my mother, who has been diagnosed with rheumatoid arthritis. It is very effective. She takes it with hyaluronic acid and is sure to drink plenty of water in the morning.
9
Significant pain relief
For years, I struggled with hernia, protrusions, and rheumatoid arthritis. After trying glucosamine, chondroitin, and MSM with OptiMSM, I was surprised by the significant decrease in pain. I feel much better now and appreciate the natural ingredients. At 28, I’m cautious about what I consume. The packaging is convenient and safe for storage. I highly recommend this product for anyone dealing with similar joint issues.
References
- Notarnicola A, Tafuri S, Fusaro L, Moretti L, Pesce V, et al. The "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis. Adv Ther. 2011;28:894. 10.1007/s12325-011-0068-3
Data last updated:
